Lawrence Talbot is the son of a family steeped in wealth and power. While on vacation in Europe his life was changed forever when he was bitten by a lycanthrope and cursed to walk the earth for the rest of eternity as an immortal monster driven by rage and an unstoppable hunger for human prey. No longer a man, not fully a beast, Talbot was one of the damned: a werewolf.
After apparently dying at the hands of his loved ones, Talbot awakes in the back of a car hurtling down a deserted road, evading gunfire from another vehicle in hot pursuit. The driver of his car gets him to safety and informs him the persons following them are from a heretical cult dedicated to the extermination of all those marked by the sign of the Wolf.
As Talbot places his trust in the hands of these new friends, an order whose stated mission is to protect werewolves, and learns of the origins of the werewolf curse, he slowly starts to realize that he is actually in more danger than he could imagine and that his saviors have evil intentions all their own for him.